MEMY-504
Biomaterials and Biomedical Engineering

Course Type: Core
Semester: Second
ECTS Credits: 10

Syllabus

Biomaterials and Biomedical Engineering

Biomaterials overview: Natural and synthetic biomaterials used in biomedicine (metal, metal alloys, ceramics, natural and synthetic polymers). Definitions and properties.
Functionalization and design: Principles of biomaterial functionalization. Rational design of synthetic biomaterials.
Tissue Engineering: Principles in Tissue Engineering. Bone, cartilage, dental, cardiovascular tissue engineering. Cell adhesion.
Mechanical properties and biocompatibility: Mechanical properties and biocompatibility of implantable biomaterials.
Mathematical modelling: Methods & tools for mathematical modelling of tissue constructs and biomedical systems: solid mechanics, fluid mechanics, dynamic systems.
Biofabrication: Biofabrication methods: capabilities, technologies, hardware.
Applications: Applications of biomaterials in biomedical engineering.

Learning Outcomes

The course outline includes the study of biomaterials and biomolecules, their physicochemical and mechanical properties, their degradation mechanisms, their biocompatibility criteria and evaluation, the biological responses following an implantation. The learning goals that students should have achieved at the end of the lesson are the following:

To become familiar with the properties and attributes of biomaterials.
To become familiar with biomaterial functionalization methodologies.
To be able for principle-based design of biomaterials and apply them in biomedical research and medicine.
To know the basic methods for the mathematical modelling of tissue constructs and biomedical systems.
To understand the need of biomolecule functionalization.
To consolidate the notions of the structural mechanisms used by Nature to create materials with defined properties.
To use their knowledge in the design of biocompatible materials.
To be conceptually prepared to perform a Masters thesis in a research laboratory in the area of biomolecules, biomaterials, bioengineering, tissue engineering and regenerative medicine.

Suggested Bibliography

Bioconjugate Techniques, Greg T. Hermanson, Academic Press, Inc., 2008.
J. S. Temenoff, A. G. Mikos, Biomaterials: The Intersection of Biology and Materials Science, 2nd edition, Pearson, 2022.
C. M. Agrawal, J. L. Ong, M. R. Appleford, G. Mani, "Introduction to Biomaterials Basic Theory with Engineering Applications", Cambridge Texts in Biomedical Engineering, 2013.
"An Introduction to Biomaterials, Second edition" Ed. J. Hollinger, Taylors and Francis, 2012.
J.P. Fisher, A.G. Mikos, J.D. Bronzino, "Tissue Engineering", CRC Press, 2007.
Cindy Chung, Jason A. Burdick, Engineering cartilage tissue, Advanced Drug Delivery Reviews 60, 243–262, 2008.
B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, "Molecular Biology of the Cell, 4th edition", Garland Science 2002, chapter 19.
Stephanie Willerth, Shelly Sakiyama-Elbert, Stem book, Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery.

Related academic journals

Tissue Engineering Part A, B & C, Mary Ann Liebert
Journal of Tissue Engineering and Regenerative Medicine, Wiley
Biomaterials, Elsevier
Acta Biomaterialia, Elsevier
Advanced Healthcare Materials, Wiley
Biomaterials Science and Engineering, ACS
Biomaterials Science, RCS
Biomacromolecules, ACS
Annals of biomedical engineering, Springer
Nature biomedical engineering, Springer
Nature reviews bioengineering, Springer

MEMY-504Biomaterials and Biomedical Engineering